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Physiology (Bethesda). 2014 Sep;29(5):325-33. doi: 10.1152/physiol.00011.2014.

Melatonin: exceeding expectations.

Author information

1
Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas; and reiter@uthscsa.edu.
2
Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas; and.
3
Departamento de Quimica, Universidad Autonoma Metropolitana-Iztapalapa, Mexico D.F., Mexico.

Abstract

Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.

PMID:
25180262
DOI:
10.1152/physiol.00011.2014
[Indexed for MEDLINE]
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