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Tumour Biol. 2014 Dec;35(12):12339-44. doi: 10.1007/s13277-014-2546-0. Epub 2014 Sep 2.

MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2.

Author information

1
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Harbin Medical University, 150001, Harbin, China.

Abstract

Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies suggest that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC and a potentially novel diagnostic and therapeutic target for OC treatment.

PMID:
25179841
DOI:
10.1007/s13277-014-2546-0
[Indexed for MEDLINE]

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