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Clin Immunol. 2014 Nov;155(1):42-6. doi: 10.1016/j.clim.2014.08.009. Epub 2014 Aug 30.

Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.

Author information

1
Division of Allergy, Immunology and Rheumatology, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.
2
Department of Pathophysiology, National University of Athens, Athens, Greece.
3
IMMCO Diagnostics Inc., Buffalo, NY 14228, USA.
4
Division of Allergy, Immunology and Rheumatology, Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA. Electronic address: jambrus@buffalo.edu.

Abstract

Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.

KEYWORDS:

Anti-La;; Anti-Ro;; Anti-salivary gland protein 1 (SP1); Rheumatoid arthritis;; Sjogren's syndrome;

PMID:
25178982
DOI:
10.1016/j.clim.2014.08.009
[Indexed for MEDLINE]

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