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Chem Commun (Camb). 2014 Oct 18;50(81):12181-4. doi: 10.1039/c4cc05047a.

Acid-catalyzed acylation reaction via C-C bond cleavage: a facile and mechanistically defined approach to synthesize 3-acylindoles.

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1
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. fuweili@licp.cas.cn.

Abstract

A facile acid-catalyzed acylation of indoles with 1,3-dione as an eco-friendly acylating agent was developed. This protocol combines C-C bond cleavage and heterocyclic C-H bond functionalization to form new C-C bonds. Based on the detailed mechanistic studies, a credible mechanistic pathway was proposed.

PMID:
25177754
DOI:
10.1039/c4cc05047a
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