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Biomed Res Int. 2014;2014:870267. doi: 10.1155/2014/870267. Epub 2014 Aug 11.

Myeloid-derived microRNAs, miR-223, miR27a, and miR-652, are dominant players in myeloid regulation.

Author information

1
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest 1089, Hungary.
2
Division of Molecular & Cellular Science, The School of Pharmacy, University Park Science Road, Nottingham NG7 2RD, UK.

Abstract

In the past few years expanding knowledge has been accumulated about the role of microRNAs (miRNAs) not only in hematopoiesis and cancer, but also in inflammatory and infectious diseases. Regarding myeloid cells, our knowledge is relatively insufficient, therefore we intended to collect the available data of miRNA profiles of myeloid cells. In addition to a rather general myeloid regulator miR-223, two other miRNAs seem to be useful subjects in understanding of myeloid miRNA biology: miR-27a and miR-652. We review functions of these three miRNAs and other myeloid miRNAs focusing on their roles in monocytes, neutrophils, eosinophils, basophils and mast cells.

PMID:
25177699
PMCID:
PMC4142666
DOI:
10.1155/2014/870267
[Indexed for MEDLINE]
Free PMC Article

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