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Dement Geriatr Cogn Dis Extra. 2014 Jul 11;4(2):252-62. doi: 10.1159/000364816. eCollection 2014 May.

Serum metabolomic biomarkers of dementia.

Author information

1
Department of Integrative Medical Biology, Umeå University, Stockholm, Sweden ; Institute of Environmental Medicine, Stockholm, Sweden.
2
Department of Chemistry, Computational Life Science Cluster, Umeå University, Stockholm, Sweden.
3
Department of Clinical Sciences, Psychiatry, Umeå University, Stockholm, Sweden.
4
Department of Psychology, Umeå University, Stockholm, Sweden ; Institute of Clinical Dentistry, University of Tromsø, Tromsø, Norway.
5
Department of Occupational and Environmental Medicine, Umeå University, Stockholm, Sweden.
6
Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Stockholm, Sweden.
7
Umeå Center for Functional Brain Imaging, Umeå, Stockholm, Sweden ; Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
8
Department of Integrative Medical Biology, Umeå University, Stockholm, Sweden ; Department of Radiation Sciences, Umeå University, Stockholm, Sweden ; Umeå Center for Functional Brain Imaging, Umeå, Stockholm, Sweden.

Abstract

AIMS:

This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis.

METHODS:

Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry.

RESULTS:

A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid.

CONCLUSIONS:

Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.

KEYWORDS:

Alzheimer's disease; Early diagnosis; Gas chromatography; Memory; Vascular dementia

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