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Neoreviews. 2014 May 1;15(5):e177-e186.

Hypoxic ischemic brain injury: Potential therapeutic interventions for the future.

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Department of Pediatrics, University of Chicago 900 East 57th Street Chicago IL 60637.
Department of Neurology, University of Chicago 900 East 57th Street Chicago IL 60637.


Perinatal hypoxic-ischemic brain injury is a common problem with potentially devastating impact on neurodevelopmental outcomes. While therapeutic hypothermia, the first available treatment for this disease, reduces the risk of death or major neurodevelopmental disability, the risk of major neurologic morbidity following HI remains significant. Basic research has identified cellular mechanisms that mediate neuronal death. This article reviews the cellular processes induced that lead to brain injury following HI, and identify treatments currently under investigation for potential translation to clinical trials.


F-68; allopurinol; erythropoietin; excitotoxicity; lipid peroxidation; melatonin; nitric oxide; oxidative stress; poloxamer 188; topiramate; xenon

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