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Nat Rev Cancer. 2014 Oct;14(10):683-91. doi: 10.1038/nrc3798. Epub 2014 Sep 1.

Stem cell-based therapies for cancer treatment: separating hope from hype.

Author information

1
Molecular Neurotherapy and Imaging Laboratory and the Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
2
Molecular Neurotherapy and Imaging Laboratory and the Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA; and the Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

Stem cell-based therapies are emerging as a promising strategy to tackle cancer. Multiple stem cell types have been shown to exhibit inherent tropism towards tumours. Moreover, when engineered to express therapeutic agents, these pathotropic delivery vehicles can effectively target sites of malignancy. This perspective considers the current status of stem cell-based treatments for cancer and provides a rationale for translating the most promising preclinical studies into the clinic.

PMID:
25176333
PMCID:
PMC4234304
DOI:
10.1038/nrc3798
[Indexed for MEDLINE]
Free PMC Article

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