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Am J Case Rep. 2014 Aug 31;15:368-73. doi: 10.12659/AJCR.891416.

Influenza vaccine-induced CNS demyelination in a 50-year-old male.

Author information

1
Cracchiolo Inpatient Rehabilitation Center, St. John Hospital & Medical Center, Detroit, USA.

Abstract

PATIENT:

Male, 50.

FINAL DIAGNOSIS:

Acute post-vaccination CNS demyelinating disorder.

SYMPTOMS:

Blurred vision • hemiparesis • hemiplegia • hypertonia • itching • paresthesia.

MEDICATION:

-.

CLINICAL PROCEDURE:

MRI.

SPECIALTY:

Neurology.

OBJECTIVE:

Rare disease.

BACKGROUND:

There are several categories of primary inflammatory demyelinating disorders, which comprise clinically similar neurologic sequelae. Of interest, clinically isolated syndrome (CIS) and acute disseminated encephalomyelitis (ADEM) are 2 demyelinating conditions of the central nervous system (CNS), whose clinical similarity pose a significant challenge to definitive diagnosis. Yet, both remain important clinical considerations in patients with neurologic signs and symptoms in the context of recent vaccination.

CASE REPORT:

We report a case of a 50-year-old Caucasian male with a course of progressive, focal, neurologic deficits within 24 h after receiving the influenza vaccine. Subsequent work-up revealed the possibility of an acute central nervous system (CNS) demyelinating episode secondary to the influenza vaccine, best described as either CIS or ADEM.

CONCLUSIONS:

Case reports of CNS demyelination following vaccinations have been previously noted, most often occurring in the context of recent influenza vaccination. This report serves to document a case of CNS demyelination occurring 24 h after influenza vaccination in a middle-aged patient, and will describe some salient features regarding the differential diagnosis of CIS and ADEM, as well as their potential management.

PMID:
25175754
PMCID:
PMC4159247
DOI:
10.12659/AJCR.891416
[Indexed for MEDLINE]
Free PMC Article

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