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Lung Cancer. 2014 Oct;86(1):5-13. doi: 10.1016/j.lungcan.2014.08.008. Epub 2014 Aug 18.

Is (18)F-FDG PET useful in predicting the WHO grade of malignancy in thymic epithelial tumors? A meta-analysis.

Author information

1
Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
2
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Unit of Thoracic Surgery, San Giovanni Hospital, Bellinzona, Switzerland.
4
Unit of Thoracic Surgery, University of Turin, Turin, Italy.
5
Unit of Thoracic Surgery, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. Electronic address: filippo_lococo@yahoo.it.

Abstract

AIM:

To perform a systematic review and meta-analysis of published data on the role of fluorine-18-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in predicting the WHO grade of malignancy in thymic epithelial tumors (TETs).

METHODS:

A comprehensive literature search of studies published up to March 2014 was performed. Data on maximum standardized uptake value (SUVmax) in patients with low-risk thymomas (A, AB, B1), high-risk thymomas (B2, B3) and thymic carcinomas (C) according to the WHO classification were collected when reported by the retrieved articles. The comparison of mean SUVmax between low-risk thymomas, high-risk thymomas and thymic carcinomas was expressed as weighted mean difference (WMD) and a pooled WMD was calculated including 95% confidence interval (95%CI).

RESULTS:

Eleven studies were selected for the meta-analysis. The pooled WMD of SUVmax between high-risk and low-risk thymomas was 1.2 (95%CI: 0.4-2.0). The pooled WMD of SUVmax between thymic carcinomas and low-risk thymomas was 4.8 (95%CI: 3.4-6.1). Finally, the pooled WMD of SUVmax between thymic carcinomas and high-risk thymomas was 3.5 (95%CI: 2.7-4.3).

CONCLUSIONS:

(18)F-FDG PET may predict the WHO grade of malignancy in TETs. In particular, we demonstrated a statistically significant difference of SUVmax between the different TETs (low-grade thymomas, high-grade thymomas and thymic carcinomas).

KEYWORDS:

FDG; Meta-analysis; PET/CT; Positron emission tomography; Thymic; Thymoma

PMID:
25175317
DOI:
10.1016/j.lungcan.2014.08.008
[Indexed for MEDLINE]

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