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Med Sci (Paris). 2014 Aug-Sep;30(8-9):790-6. doi: 10.1051/medsci/20143008018. Epub 2014 Sep 1.

[Functions of lncRNA in development and diseases].

[Article in French]

Author information

1
Inserm UMR1090 TAGC (technological advances for genomics and clinics), 13288 Marseille, France - Université Aix-Marseille, UMR1090 TAGC, 13288 Marseille, France.
2
Inserm UMR1090 TAGC (technological advances for genomics and clinics), 13288 Marseille, France - Université Aix-Marseille, UMR1090 TAGC, 13288 Marseille, France - Polytech Marseille, parc scientifique de Luminy, Marseille, France.

Abstract

The transcription of essentially the entire eukaryotic genome generates a myriad of non-coding RNA species that show complex overlapping patterns of expression and regulation. In the last decade, several large scale genomic analyses have shed light on the widespread existence of long non-coding RNAs (lncRNAs) in mammals. Although the function of most lncRNAs remains unknown, many of them have been suggested to play important roles in the regulation of gene expression during normal development and diseases, including cancers. Indeed, functional studies have demonstrated that lncRNAs participate in various biological processes, including reprogramming of pluripotent stem cells, oncogenic progression and cell cycle regulation. In this review, we summarize recent findings about the biology of lncRNAs and their functions in normal and pathological development in mammals.

PMID:
25174757
DOI:
10.1051/medsci/20143008018
[Indexed for MEDLINE]
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