Format

Send to

Choose Destination
Diabetes Res Clin Pract. 2014 Oct;106(1):e3-6. doi: 10.1016/j.diabres.2014.08.004. Epub 2014 Aug 12.

Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?

Author information

1
Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia.
2
Discipline of Medicine, The University of Adelaide, Adelaide, South Australia 5000, Australia; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia 5000, Australia. Electronic address: chris.rayner@adelaide.edu.au.

Abstract

Metformin was reported to increase plasma intact glucagon-like peptide-1 (GLP-1) concentrations in type 2 diabetes. This is, at least partly, attributable to stimulation of GLP-1 secretion. A reduction in soluble dipeptidyl peptidase-4 activity may also make a modest contribution.

KEYWORDS:

Dipeptidyl peptidase-4; Enteral nutrition; Glucagon-like peptide-1; Metformin

PMID:
25172519
DOI:
10.1016/j.diabres.2014.08.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center