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J Mol Cell Cardiol. 2015 Jan;78:142-53. doi: 10.1016/j.yjmcc.2014.08.015. Epub 2014 Aug 27.

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury.

Author information

1
Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
2
Cardiovascular Institute, Azienda Ospedaliero-Universitaria S. Anna and LTTA Center, Ferrara, Italy.
3
Department of Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland.
4
Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. Electronic address: pnp@unife.it.

Abstract

The mitochondrial permeability transition is a key event in cell death. Intense research efforts have been focused on elucidating the molecular components of the mitochondrial permeability transition pore (mPTP) to improve the understanding and treatment of various pathologies, including neurodegenerative disorders, cancer and cardiac diseases. Several molecular factors have been proposed as core components of the mPTP; however, further investigation has indicated that these factors are among a wide range of regulators. Thus, the scientific community lacks a clear model of the mPTP. Here, we review the molecular factors involved in the regulation and formation of the mPTP. Furthermore, we propose that the mitochondrial ATP synthase, specifically its c subunit, is the central core component of the mPTP complex. Moreover, we discuss the involvement of the mPTP in ischemia and reperfusion as well as the results of clinical studies targeting the mPTP to ameliorate ischemia-reperfusion injury. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

KEYWORDS:

Apoptosis; Cell death; Ischemia reperfusion injury; Mitochondrial permeability transition pore, MPTP; Necrosis; Permeability transition pore, PTP

PMID:
25172387
DOI:
10.1016/j.yjmcc.2014.08.015
[Indexed for MEDLINE]

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