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Brain Res. 2014 Oct 24;1586:109-17. doi: 10.1016/j.brainres.2014.08.044. Epub 2014 Aug 27.

Reduced fiber integrity and cognitive control in adolescents with internet gaming disorder.

Author information

1
School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China.
2
School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China. Electronic address: kyuan@xidian.edu.cn.
3
Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.
4
Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China.
5
School of Mathematics, Physics and Biological Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China.
6
School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China. Electronic address: wqin@xidian.edu.cn.
7
School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China; Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China.

Abstract

The association between the impaired cognitive control and brain regional abnormalities in Internet gaming disorder (IGD) adolescents had been validated in numerous studies. However, few studies focused on the role of the salience network (SN), which regulates dynamic communication among brain core neurocognitive networks to modulate cognitive control. Seventeen IGD adolescents and 17 healthy controls participated in the study. By combining resting-state functional connectivity and diffusion tensor imaging (DTI) tractography methods, we examined the changes of functional and structural connections within SN in IGD adolescents. The color-word Stroop task was employed to assess the impaired cognitive control in IGD adolescents. Correlation analysis was carried out to investigate the relationship between the neuroimaging indices and behavior performance in IGD adolescents. The impaired cognitive control in IGD was validated by more errors during the incongruent condition in color-word Stroop task. The right SN tract showed the decreased fractional anisotropy (FA) in IGD adolescents, though no significant differences of functional connectivity were detected. Moreover, the FA values of the right SN tract were negatively correlated with the errors during the incongruent condition in IGD adolescents. Our results revealed the disturbed structural connectivity within SN in IGD adolescents, which may be related with impaired cognitive control. It is hoped that the brain-behavior relationship from network perspective may enhance the understanding of IGD.

KEYWORDS:

Diffusion tensor imaging (DTI); Fractional anisotropy (FA); Internet gaming disorder (IGD); Resting-state; Salience network (SN)

PMID:
25171806
DOI:
10.1016/j.brainres.2014.08.044
[Indexed for MEDLINE]
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