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Am J Cardiol. 2014 Oct 15;114(8):1215-6. doi: 10.1016/j.amjcard.2014.07.042. Epub 2014 Jul 30.

Changes in muscle strength in patients with statin myalgia.

Author information

1
Department of Cardiology, Hartford Hospital, Hartford, Connecticut. Electronic address: Gregory.panza@hhchealth.org.
2
Department of Cardiology, Hartford Hospital, Hartford, Connecticut; Department of Health Sciences, University of Hartford, West Hartford, Connecticut.
3
Department of Cardiology, Hartford Hospital, Hartford, Connecticut.

Abstract

Statins can produce myalgia or muscle pain, which may affect medication adherence. We measured the effects of statins on muscle strength in patients with previous statin myalgia. Leg isokinetic extension average power at 60° per second (-8.8 ± 10.5N-M, p = 0.02) and average peak torque at 60° per second (-14.0 ± 19.7N-M, p = 0.04) decreased slightly with statin use, but 8 of 10 other variables for leg strength did not change (all p >0.13). Handgrip, muscle pain, respiratory exchange ratio, and daily activity also did not change (all p >0.09). In conclusion, statin myalgia is not associated with reduced muscle strength or muscle performance.

PMID:
25171803
DOI:
10.1016/j.amjcard.2014.07.042
[Indexed for MEDLINE]

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