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Learn Mem. 2014 May 15;21(6):305-10. doi: 10.1101/lm.034827.114. Print 2014 Jun.

Molecular correlates of cortical network modulation by long-term sensory experience in the adult rat barrel cortex.

Author information

1
Department of Neurocognition, Faculty of Psychology and Neuroscience, Maastricht University, 6229 EV Maastricht, The Netherlands Department of Molecular Animal Physiology, Radboud University, Donders Institute for Brain, Cognition and Behaviour (Centre for Neuroscience), Nijmegen Centre for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands.
2
Department of Molecular Animal Physiology, Radboud University, Donders Institute for Brain, Cognition and Behaviour (Centre for Neuroscience), Nijmegen Centre for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands.

Abstract

Modulation of cortical network connectivity is crucial for an adaptive response to experience. In the rat barrel cortex, long-term sensory stimulation induces cortical network modifications and neuronal response changes of which the molecular basis is unknown. Here, we show that long-term somatosensory stimulation by enriched environment up-regulates cortical expression of neuropeptide mRNAs and down-regulates immediate-early gene (IEG) mRNAs specifically in the barrel cortex, and not in other brain regions. The present data suggest a central role of neuropeptides in the fine-tuning of sensory cortical circuits by long-term experience.

PMID:
25171421
PMCID:
PMC4024621
DOI:
10.1101/lm.034827.114
[Indexed for MEDLINE]
Free PMC Article

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