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Cell. 2014 Aug 28;158(5):980-987. doi: 10.1016/j.cell.2014.08.005.

Emerging roles of RNA modification: m(6)A and U-tail.

Author information

1
IBS Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
2
IBS Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. Electronic address: narrykim@snu.ac.kr.

Abstract

Although more than 100 types of RNA modification have been described thus far, most of them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent developments have unveiled that at least some of the modifications are considerably abundant and widely conserved. This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m(6)A) and uridylation (U-tail).

PMID:
25171402
DOI:
10.1016/j.cell.2014.08.005
[Indexed for MEDLINE]
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