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Cell. 2014 Aug 28;158(5):973-975. doi: 10.1016/j.cell.2014.08.013.

Sending mixed messages for cell population control.

Author information

1
Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
2
Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: wendell.lim@ucsf.edu.

Abstract

Cells often receive signals to proliferate, but how population density is controlled is unclear. Hart et al. now show that a single secreted molecule that instructs both proliferation and death in T cells establishes a bistable response: the population is driven to either extinction or to a homeostatically defined density.

PMID:
25171399
PMCID:
PMC4351990
DOI:
10.1016/j.cell.2014.08.013
[Indexed for MEDLINE]
Free PMC Article

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