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Cell. 2014 Aug 28;158(5):971-2. doi: 10.1016/j.cell.2014.08.010.

Neutralizing the HIV reservoir.

Author information

  • 1Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • 2Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jzack@ucla.edu.

Abstract

Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.

PMID:
25171398
PMCID:
PMC4182933
DOI:
10.1016/j.cell.2014.08.010
[PubMed - indexed for MEDLINE]
Free PMC Article
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