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Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2372-7. doi: 10.1161/ATVBAHA.114.303218. Epub 2014 Aug 28.

Signaling pathways in the specification of arteries and veins.

Author information

1
From the IFOM, FIRC Institute of Molecular Oncology, Milan, Italy (M.C., M.F.M., E.D.); and Department of Biosciences, University of Milan, Milan, Italy (E.D.).
2
From the IFOM, FIRC Institute of Molecular Oncology, Milan, Italy (M.C., M.F.M., E.D.); and Department of Biosciences, University of Milan, Milan, Italy (E.D.). elisabetta.dejana@ifom.eu.

Abstract

The establishment of arterial and venous identity of endothelial cells is critical for the proper anatomic configuration and function of the vascular tree. Arterial and venous specification of endothelial cells is determined by genetic factors, although surrounding cells and hemodynamic forces may also contribute to vascular remodeling. This review provides an overview of the signaling pathways and related transcription factors implicated in differentiation of endothelial cells. We will discuss, in particular, the role of upstream and downstream effectors of Wnt, Sox, and Notch pathways. The understanding of the molecular mechanisms that orchestrate endothelial differentiation may have therapeutic relevance for diseases such as atherosclerosis, arteriovenous malformations, aneurysms, and others.

KEYWORDS:

endothelial cells

PMID:
25169934
DOI:
10.1161/ATVBAHA.114.303218
[Indexed for MEDLINE]

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