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Cephalalgia. 2015 May;35(6):500-7. doi: 10.1177/0333102414547141. Epub 2014 Aug 28.

Candidate-gene association study searching for genetic factors involved in migraine chronification.

Author information

1
Department of Neurology, Leiden University Medical Center (LUMC), the Netherlands Department of Psychiatry, Leiden University Medical Center (LUMC), the Netherlands.
2
Headache and Neurological Pain Research Group, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona.
3
Department of Human Genetics, Leiden University Medical Center (LUMC), the Netherlands.
4
Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, United Kingdom FORMI, Oslo University Hospital, Norway Department of Neurology, Oslo University Hospital, Norway Institute of Clinical Medicine, University of Oslo, Norway.
5
Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
6
Stroke Genetics and Pharmacogenetics, Fundació per la Docència i Recerca Mutua Terrassa, Spain Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universidad Autonoma de Barcelona, Spain.
7
Pediatric Neurology Research Group, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Spain.
8
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain Centre for Biomedical Network Research on Rare Diseases (CIBERER), Spain.
9
Department of Epidemiology, Erasmus University Medical Center, the Netherlands.
10
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain Centre for Biomedical Network Research on Rare Diseases (CIBERER), Spain Institute of Biomedicine of the University of Barcelona (IBUB), Spain.
11
Neurology Department, Hospital Universitari Vall d'Hebron (HUVH), Spain.
12
Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universidad Autonoma de Barcelona, Spain Neurology Department, Hospital Universitari Vall d'Hebron (HUVH), Spain.
13
Department of Neurology, Leiden University Medical Center (LUMC), the Netherlands.
14
Department of Neurology, Leiden University Medical Center (LUMC), the Netherlands Department of Human Genetics, Leiden University Medical Center (LUMC), the Netherlands.
15
Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, United Kingdom Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, USA Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
16
FORMI, Oslo University Hospital, Norway Department of Neurology, Oslo University Hospital, Norway Institute of Clinical Medicine, University of Oslo, Norway.
17
Headache and Neurological Pain Research Group, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona Neurology Department, Hospital Universitari Vall d'Hebron (HUVH), Spain ppozo@vhebron.net.

Abstract

INTRODUCTION:

Chronic migraine (CM) is at the severe end of the clinical migraine spectrum, but its genetic background is unknown. Our study searched for evidence that genetic factors are involved in the chronification process.

METHODS:

We initially selected 144 single-nucleotide polymorphisms (SNPs) from 48 candidate genes, which we tested for association in two stages: The first stage encompassed 262 CM patients, the second investigated 226 patients with high-frequency migraine (HFM). Subsequently, SNPs with p values < 0.05 were forwarded to the replication stage containing 531 patients with CM or HFM.

RESULTS:

Eight SNPs were significantly associated with CM and HFM in the two-stage phase. None survived replication in the third stage.

DISCUSSION:

We present the first comprehensive genetic association study for migraine chronification. There were no significant findings. Future studies may benefit from larger, genome-wide data sets or should use other genetic approaches to identify genetic factors involved in migraine chronification.

KEYWORDS:

Chronic migraine; association studies; genetics; high-frequency migraine

PMID:
25169732
DOI:
10.1177/0333102414547141
[Indexed for MEDLINE]

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