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Angew Chem Int Ed Engl. 2014 Oct 13;53(42):11346-50. doi: 10.1002/anie.201403480. Epub 2014 Aug 28.

Transient substrate-induced catalyst formation in a dynamic molecular network.

Author information

1
Centre for Systems Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen (The Netherlands) http://www.otto-lab.com.

Abstract

In biology enzyme concentrations are continuously regulated, yet for synthetic catalytic systems such regulatory mechanisms are underdeveloped. We now report how a substrate of a chemical reaction induces the formation of its own catalyst from a dynamic molecular network. After complete conversion of the substrate, the network disassembles the catalyst. These results open up new opportunities for controlling catalysis in synthetic chemical systems.

KEYWORDS:

aza-Cope rearrangement; combinatorial chemistry; dynamic molecular networks; supramolecular chemistry; systems chemistry

PMID:
25169198
DOI:
10.1002/anie.201403480
[Indexed for MEDLINE]

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