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Adv Chronic Kidney Dis. 2014 Sep;21(5):426-33. doi: 10.1053/j.ackd.2014.06.005.

APOL1 kidney risk alleles: population genetics and disease associations.

Author information

1
Basic Science Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD; and Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
2
Basic Science Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Leidos Biomedical Research Inc., Frederick National Laboratory, Frederick, MD; and Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD. Electronic address: winklerc@mail.nih.gov.

Abstract

APOL1 kidney disease is a unique case in the field of the genetics of common disease: 2 variants (termed G1 and G2) with high population frequency have been repeatedly associated with nondiabetic CKDs, with very strong effect size (odds ratios 3-29) in populations of sub-Saharan African descent. This review provides an update on the spectrum of APOL1 kidney disease and on the worldwide distribution of these kidney risk variants. We also summarize the proper way to run a recessive analysis on joint and independent effects of APOL1 G1 and G2 kidney risk variants.

KEYWORDS:

APOL1 demographics; African admixture; Apolipoprotein L1; Chronic kidney disease; Glomerular disease

PMID:
25168832
PMCID:
PMC4157456
DOI:
10.1053/j.ackd.2014.06.005
[Indexed for MEDLINE]
Free PMC Article

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