Format

Send to

Choose Destination
Int J Surg. 2014;12 Suppl 2:S47-S49. doi: 10.1016/j.ijsu.2014.08.382. Epub 2014 Aug 26.

Breast conserving treatment for ductal carcinoma in situ in the elderly: can radiation therapy be avoided? Our experience.

Author information

1
Breast Unit, A.O. IRCCS Arcispedale S.M.N, Via Risorgimento 80 42120 Reggio Emilia, Italy. Electronic address: giuseppe.falco@asmn.re.it.
2
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. Electronic address: nicola.rocco@unimi.it.
3
Breast Unit, A.O. U. Second University of Naples, Naples, Italy. Electronic address: eugenio.procacini@unina2.it.
4
School of Medicine, Second University of Naples, Naples, Italy. Electronic address: mg.sommella@gmail.com.
5
University Polytechnic of the Marche, Ancona, Italy. Electronic address: danielebordoni@alice.it.
6
Breast Unit, A.O. IRCCS Arcispedale S.M.N, Via Risorgimento 80 42120 Reggio Emilia, Italy. Electronic address: eugenio.cenini@asmn.re.it.
7
Breast Unit, A.O. IRCCS Arcispedale S.M.N, Via Risorgimento 80 42120 Reggio Emilia, Italy. Electronic address: fabio.castagnetti@asmn.re.it.
8
Department of Advanced Biomedical Sciences - Section of Imaging, University Federico II of Naples, Italy. Electronic address: vincenzosabatino@yahoo.it.
9
Department of Gastroenterology, Endocrinology and Surgery, University Federico II of Naples, Naples, Italy. Electronic address: rita.compagna@libero.it.
10
Department of Gastroenterology, Endocrinology and Surgery, University Federico II of Naples, Naples, Italy. Electronic address: ga.dellacorte@gmail.com.
11
Department of Gastroenterology, Endocrinology and Surgery, University Federico II of Naples, Naples, Italy. Electronic address: antonello.accurso@unina.it.
12
Department of Gastroenterology, Endocrinology and Surgery, University Federico II of Naples, Naples, Italy. Electronic address: bramato@unina.it.
13
Breast Unit, A.O. IRCCS Arcispedale S.M.N, Via Risorgimento 80 42120 Reggio Emilia, Italy. Electronic address: guglielmo.ferrari@asmn.re.it.

Abstract

INTRODUCTION:

Ductal Carcinoma In Situ (DCIS) is a heterogeneous, pre-malignant disease accounting for 15-20% of all new breast cancers. If appropriately managed, DCIS has a small chance of impacting on patient life expectancy. Despite the possibility of a further recurrence or of a development in an invasive form, we are unable to select treatment of choice especially in the elderly. In particularly we risk an overtreatment of women at low risk of progression to invasive breast cancer. The aim of this study was to retrospectively evaluate the outcome of elderly patients affected by DCIS not undergoing Radiation Therapy (RT) after Breast Conserving Surgery (BCS).

MATERIAL AND METHODS:

We reviewed our prospectively-maintained database from 1998 to 2013, selecting all women over 65 years old diagnosed with DCIS who did not receive RT for personal choice. We considered two groups, according to the risk of local recurrence (Low Risk (Group 1) vs. High Risk (Group 2)).

RESULTS:

We identified 44 cases of DCIS treated with surgery alone or with surgery followed by adjuvant tamoxifen. 24 patients presented low risk of local recurrence (Group 1) and 20 had characteristics associated to high risk of local recurrence (Group 2). At a median follow-up of 66.3 months, no local recurrences have been described in group 1. No patients presented distant metastases, while 4 patients died for other causes. At a median follow-up of 72 months we observed 5 local recurrences in the second group (p < 0.05).

CONCLUSION:

Our results suggest that radiation therapy can be safely avoided in a selected group of elderly patients affected by DCIS.

KEYWORDS:

Breast cancer; Breast conserving treatment; Ductal carcinoma in situ; Radiation therapy

PMID:
25167849
DOI:
10.1016/j.ijsu.2014.08.382
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center