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Cancer Med. 2015 Jan;4(1):101-3. doi: 10.1002/cam4.325. Epub 2014 Aug 28.

Quadruple wild-type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways.

Author information

1
Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; "Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna, Italy.

Abstract

A subset of GISTs lack mutations in the KIT/PDGFRA or RAS pathways and yet retain an intact succinate dehydrogensase (SDH) complex. We propose that these KIT/PDGFRA/SDH/RAS-P WT GIST tumors be designated as quadruple wild-type (WT) GIST. Further molecular and clinicophatological characterization of quadruple WT GIST will help to determine their prognosis as well as assist in the optimization of medical management, including clinical test of novel therapies.

KEYWORDS:

BRAF; GIST; NF-1; RAS; SDH deficiency; SDHA; SDHB; gastrointestinal stromal tumors; quadruple WT; quadruple negative; wild type

PMID:
25165019
PMCID:
PMC4312123
DOI:
10.1002/cam4.325
[Indexed for MEDLINE]
Free PMC Article

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