Format

Send to

Choose Destination
Ann Neurol. 2014 Nov;76(5):719-26. doi: 10.1002/ana.24264. Epub 2014 Sep 17.

White matter hyperintensities and hypobaric exposure.

Author information

1
US Air Force School of Aerospace Medicine, Aerospace Medicine Consultation Division, Wright-Patterson Air Force Base, OH; Department of Neurology, University of Texas Health Sciences Center, San Antonio, TX; Department of Neurology, 59th Medical Wing, Lackland Air Force Base, TX.

Abstract

OBJECTIVE:

Demonstrate that occupational exposure to nonhypoxic hypobaria is associated with subcortical white matter hyperintensities (WMHs) on fluid-attenuated inversion recovery magnetic resonance imaging (MRI).

METHODS:

Eighty-three altitude chamber personnel (PHY), 105 U-2 pilots (U2P), and 148 age- controlled and health-matched doctorate degree controls (DOC) underwent high-resolution MRI. Subcortical WMH burden was quantified as count and volume of subcortical WMH lesions after transformation of images to the Talairach atlas-based stereotactic frame.

RESULTS:

Subcortical WMHs were more prevalent in PHY (volume p = 0.011/count p = 0.019) and U2P (volume p < 0.001/count p < 0.001) when compared to DOC, whereas PHY were not significantly different than U2P.

INTERPRETATION:

This study provides strong evidence that nonhypoxic hypobaric exposure may induce subcortical WMHs in a young, healthy population lacking other risk factors for WMHs and adds this occupational exposure to other environmentally related potential causes of WMHs. Ann Neurol 2014;76:719-726.

PMID:
25164539
PMCID:
PMC4219408
DOI:
10.1002/ana.24264
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center