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Nanoscale. 2014 Oct 21;6(20):11676-80. doi: 10.1039/c4nr02623c. Epub 2014 Aug 28.

Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging.

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1
Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), UMR 7504, CNRS, Université de Strasbourg, 23, rue du Loess, BP 43, 67034 Strasbourg Cedex 2, France. damien.mertz@ipcms.unistra.fr.

Abstract

In this article, we address the design of innovative human serum albumin (HSA)-based nanoparticles loaded with silencing RNA and grafted with gadolinium complexes having average sizes ranging from ca. 50 to 150 nm according to the siRNA/HSA composition. The non-covalent siRNA/HSA assembly is formed on isobutyramide-modified mesoporous silica and the self-supported HSA-based nanoparticles are obtained following the silica template dissolution. These original protein particles provide simultaneous magnetic resonance imaging contrast enhancement and cellular in vitro gene silencing.

PMID:
25163585
DOI:
10.1039/c4nr02623c
[Indexed for MEDLINE]
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