Format

Send to

Choose Destination
Org Biomol Chem. 2014 Oct 14;12(38):7498-502. doi: 10.1039/c4ob00860j.

Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors.

Author information

1
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA. hl379@cornell.edu.

Abstract

Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibitors.

PMID:
25163004
PMCID:
PMC4161628
DOI:
10.1039/c4ob00860j
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Royal Society of Chemistry Icon for PubMed Central
Loading ...
Support Center