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J Biol Chem. 2014 Oct 10;289(41):28129-36. doi: 10.1074/jbc.R114.592618. Epub 2014 Aug 26.

Lysosome-related organelles as mediators of metal homeostasis.

Author information

1
From the Department of Chemistry and Biochemistry and cblaby@chem.ucla.edu.
2
From the Department of Chemistry and Biochemistry and the Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095.

Abstract

Metal ion assimilation is essential for all forms of life. However, organisms must properly control the availability of these nutrients within the cell to avoid inactivating proteins by mismetallation. To safeguard against an imbalance between supply and demand in eukaryotes, intracellular compartments contain metal transporters that load and unload metals. Although the vacuoles of Saccharomyces cerevisiae and Arabidopsis thaliana are well established locales for the storage of copper, zinc, iron, and manganese, related compartments are emerging as important mediators of metal homeostasis. Here we describe these compartments and review their metal transporter complement.

KEYWORDS:

Acidocalcisome; Algae; Chlamydomonas; Permease; Plant; Subcellular Organelle; Transport; Vacuolar

PMID:
25160625
PMCID:
PMC4192468
DOI:
10.1074/jbc.R114.592618
[Indexed for MEDLINE]
Free PMC Article

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