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Invest Ophthalmol Vis Sci. 2014 Aug 26;55(9):5842-7. doi: 10.1167/iovs.14-14844.

Time course of changes in tear meniscus radius and blink rate after instillation of artificial tears.

Author information

1
School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom Höhere Fachschule für Augenoptik Köln (Cologne School of Optometry), Cologne, Germany.
2
School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom.
3
University of Waterloo, School of Optometry and Vision Science, Waterloo, Canada.
4
School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom Dr. Heiko Pult - Optometry and Vision Research, Weinheim, Germany.

Abstract

PURPOSE:

Using a novel digital meniscometer (PDM), alterations in tear meniscus radius (TMR) were measured simultaneously with blink rate (BR) following the instillation of artificial tears.

METHODS:

Central TMR and BR of 22 subjects (11 male and 11 female; mean age, 24.3 ± 2.6 SD years) were measured at baseline, and 0, 1, 5, 10, and 30 minutes after instillation of an artificial tear containing hydroxypropyl-guar and glycol (SYS) or saline (SAL). A dose of 35 μL was applied in one eye in a randomized order with a washout period between each drop.

RESULTS:

For SAL, compared to baseline TMR (0.33 ± 0.08 mm), TMR significantly increased with drop instillation (1.55 ± 0.69 mm) and at 1 minute (0.66 ± 0.36 mm; P < 0.05), but returned to baseline after 5 minutes. For SYS, TMR (0.32 ± 0.07 mm) remained significantly increased after application (1.62 ± 0.81 mm), and at 1 minute (0.81 ± 0.43 mm) and 5 minutes (0.39 ± 0.08 mm; P < 0.05). Compared to baseline BR with SAL (14.8 ± 7.7) and SYS (14.9 ± 9.4), values were significantly increased upon drop instillation (22.5 ± 11.8; 21.3 ± 11.8; P < 0.05), but returned to baseline after 1 minute. Dry eye symptoms were correlated with baseline BR (r = 0.550, P = 0.008).

CONCLUSIONS:

Results indicate that PDM can detect changes in TMR following instillation of artificial tears. Difference in residence time reflects the different viscosity of each drop. An overload with a large drop may result in an initially increased BR.

KEYWORDS:

artificial tears; blink rate; dry eye symptoms; portable digital meniscometer; tear meniscus; tear volume loss

PMID:
25159203
DOI:
10.1167/iovs.14-14844
[Indexed for MEDLINE]

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