Format

Send to

Choose Destination
Behav Brain Sci. 2015;38:e92. doi: 10.1017/S0140525X1400082X. Epub 2014 Aug 27.

A conceptual framework for the neurobiological study of resilience.

Author information

1
Neuroimaging Center Mainz (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, and Deutsches Resilienz-Zentrum Mainz (DRZ), Johannes Gutenberg University Mainz, 55131 Mainz, Germany. rkalisch@uni-mainz.de www.ftn.nic.uni-mainz.de/en/
2
Research Group Molecular Stress Physiology, Max Planck Institute of Psychiatry, 80804 Munich, Germany and Department of Psychiatry and Psychotherapy, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, and Deutsches Resilienz-Zentrum Mainz (DRZ), Johannes Gutenberg University Mainz, 55131 Mainz,Germany. muellerm@mpipsykl.mpg.de
3
Department of Psychiatry and Psychotherapy, Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center Mainz, and Deutsches Resilienz-Zentrum Mainz (DRZ), Johannes Gutenberg University Mainz, 55131 Mainz,Germany. tuescher@uni-mainz.de

Abstract

The well-replicated observation that many people maintain mental health despite exposure to severe psychological or physical adversity has ignited interest in the mechanisms that protect against stress-related mental illness. Focusing on resilience rather than pathophysiology in many ways represents a paradigm shift in clinical-psychological and psychiatric research that has great potential for the development of new prevention and treatment strategies. More recently, research into resilience also arrived in the neurobiological community, posing nontrivial questions about ecological validity and translatability. Drawing on concepts and findings from transdiagnostic psychiatry, emotion research, and behavioral and cognitive neuroscience, we propose a unified theoretical framework for the neuroscientific study of general resilience mechanisms. The framework is applicable to both animal and human research and supports the design and interpretation of translational studies. The theory emphasizes the causal role of stimulus appraisal (evaluation) processes in the generation of emotional responses, including responses to potential stressors. On this basis, it posits that a positive (non-negative) appraisal style is the key mechanism that protects against the detrimental effects of stress and mediates the effects of other known resilience factors. Appraisal style is shaped by three classes of cognitive processes--positive situation classification, reappraisal, and interference inhibition--that can be investigated at the neural level. Prospects for the future development of resilience research are discussed.

KEYWORDS:

PASTOR; adaptation; allostasis; appraisal; aversion; coping; emotion; emotion regulation; inhibition; interference; mental health; motivation; prevention; reappraisal; recovery; resilience; stress; stressor; trauma

Comment in

PMID:
25158686
DOI:
10.1017/S0140525X1400082X
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Cambridge University Press
Loading ...
Support Center