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Nat Commun. 2014 Aug 26;5:4712. doi: 10.1038/ncomms5712.

A smart and versatile theranostic nanomedicine platform based on nanoporphyrin.

Author information

1
Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA.
2
Department of Internal Medicine, Division of Hematology/Oncology, University of California Davis, Sacramento, CA 95817, USA.
3
Department of Oncology, PLA Cancer Research Institute of the Second Affiliated Hospital, Third Military Medical University, Chongqing, 400037, China.
4
National Chengdu Center for Safety Evaluation of Drugs, West China Hospital, Sichuan University, Chengdu, 610041, China.
5
Beijing institute of technology, Beijing, 100081, China.
6
NSF Center for Biophotonics Science and Technology, University of California Davis, Sacramento, CA 95817, USA.
7
Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA 95817, USA.
8
UC Davis NMR Facility, Davis, CA 95616, USA.
9
Department of Biomedical Engineering, Center for Molecular and Genomic Imaging, University of California Davis, Davis, CA 95616, USA.
10
VA Northern California Health Care System, Mather, CA.
#
Contributed equally

Abstract

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.

PMID:
25158161
PMCID:
PMC4145614
DOI:
10.1038/ncomms5712
[Indexed for MEDLINE]
Free PMC Article

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