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Clin Chest Med. 2014 Sep;35(3):495-504. doi: 10.1016/j.ccm.2014.06.005. Epub 2014 Jul 18.

Cystic fibrosis and sleep.

Author information

1
Division of Respiratory Diseases, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Mailstop 208, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: eliot.katz@childrens.harvard.edu.

Abstract

Sleep disturbances are frequently observed in cystic fibrosis (CF). The resultant sleep fragmentation, short sleep duration, and gas-exchange abnormalities are postulated to contribute to the neurocognitive, cardiovascular, and metabolic abnormalities associated with CF. There are no outcomes data to establish the optimal procedure for screening and treating CF patients for sleep-related respiratory abnormalities. Therapy with supplemental oxygen and bilevel ventilation are widely considered to be effective in the short term, but there are few evidence-based data to support long-term improvements in morbidity and mortality.

KEYWORDS:

Hypoventilation; Hypoxemia; Noninvasive ventilation; Respiratory insufficiency; Sleep-disordered breathing

PMID:
25156765
DOI:
10.1016/j.ccm.2014.06.005
[Indexed for MEDLINE]

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