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J Infect Dis. 2015 Feb 15;211(4):582-9. doi: 10.1093/infdis/jiu473. Epub 2014 Aug 25.

Infection with novel respiratory syncytial virus genotype Ontario (ON1) in adult hematopoietic cell transplant recipients, Texas, 2011-2013.

Author information

1
Department of Molecular Virology and Microbiology.
2
Departments of Infectious Diseases, Infection Control, and Employee Health, University of Texas MD Anderson Cancer Center, Houston, Texas.
3
Department of Molecular Virology and Microbiology Department of Pediatrics, Baylor College of Medicine.

Abstract

BACKGROUND:

Respiratory syncytial virus (RSV) can cause severe respiratory disease in adult hematopoietic cell transplant (HCT) recipients. RSV subgroups A and B have evolved into multiple genotypes. We report on a recently described RSV genotype (ON1) in a cohort of adult HCT recipients in Texas.

METHODS:

Twenty adult HCT recipients were enrolled as a part of an efficacy trial of ribavirin therapy. RSV identification and genotyping was performed using molecular techniques. RSV-specific neutralizing antibody (NAb) responses were measured.

RESULTS:

ON1 genotype was detected in 3 of 6 patients in the 2011-2012 season and in 8 of 14 patients in 2012-2013 season. Other genotypes detected were NA1 and BA. NAb levels were low at enrollment. Eight of 9 patients who cleared the RSV infection within 2 weeks mounted a ≥4-fold NAb response, compared with 2 of 8 who shed the virus for >2 weeks. The clinical course of those infected with ON1 was comparable to the course for individuals infected with other genotypes.

CONCLUSION:

This is the first report of RSV ON1 genotype in the United States, and ON1 genotype was dominant genotype in adult HCT recipients. Interestingly, faster viral clearance was associated with a ≥4-fold NAb response, likely indicating a reconstituted immune system.

KEYWORDS:

HCT; RSV; RSV-specific neutralizing antibody; genetic variability; immunocompromised host; novel genotype

PMID:
25156562
DOI:
10.1093/infdis/jiu473
[Indexed for MEDLINE]

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