Format

Send to

Choose Destination
Cancer Epidemiol. 2014 Oct;38(5):528-37. doi: 10.1016/j.canep.2014.07.011. Epub 2014 Aug 22.

Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom. Electronic address: m.merritt@imperial.ac.uk.
2
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom.
3
Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, N-9037 Tromsø, Norway; Department of Etiological Research, The Cancer Registry of Norway, 0310 Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, Stockholm 17177, Sweden; Folkhälsan Research Centre, Samfundet Folkhälsan, FI-00290 Helsinki, Finland.
4
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, 45110 Ioannina, Greece; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Oxford OX3 7LF, United Kingdom.
5
Aarhus University, Department of Public Health, Section for Epidemiology, Bartholins Allé 2 - Building 1260, DK-8000 Aarhus, Denmark.
6
Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
7
Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, F-94805 Villejuif, France; Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France; Institut Gustave Roussy, F-94805 Villejuif, France.
8
Cancer Epidemiology Centre, Cancer Council of Victoria, 615 St. Kilda Road, Melbourne, Victoria 3004, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Victoria 3010, Australia.
9
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
10
German Institute of Human Nutrition, Potsdam-Rehbrücke (DIfE), Department of Epidemiology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
11
Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece; Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece.
12
Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece; Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece; Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
13
Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece; Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Mikras Asias 75, Goudi, GR-115 27 Athens, Greece.
14
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Ponte Nuovo Palazzina 28 A "Mario Fiori", Via delle Oblate 4, 50141 Florence, Italy.
15
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, 20133 Milano, Italy.
16
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Corso Umberto I, 40, 80138 Naples, Italy.
17
Cancer Registry and Histopathology Unit, "Civic-M.P.Arezzo" Hospital, ASP, Via Dante N° 109, 97100 Ragusa, Italy.
18
Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza-University of Turin and Center for Cancer Prevention (CPO-Piemonte), Via Santena 7, 10126 Turin, Italy; Human Genetics Foundation (HuGeF), Via Nizza 52, 10126 Turin, Italy.
19
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom; National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Heidelberglann 100, 3584 CX Utrecht, The Netherlands.
20
Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Huispost Str. 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.
21
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Huispost Str. 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.
22
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Postboks 1046 Blindern, 0317 Oslo, Norway.
23
Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, N-9037 Tromsø, Norway.
24
Public Health Directorate, Health and Health Care Services Council, C/ Ciriaco Miguel Virgil no 9, CP 33006 Oviedo, Asturias, Spain.
25
Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Avda Gran Via 199-203, L'Hospitalet del Llobregat, 08907 Barcelona, Spain.
26
Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Cuesta del Observatorio, 4, Campus Universitario de Cartuja, 18080 Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Melchor Fernández Almagro, 3-5, 28029 Madrid, Spain.
27
CIBER de Epidemiología y Salud Pública (CIBERESP), Melchor Fernández Almagro, 3-5, 28029 Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, Ronda de Levante 11, 30008 Murcia, Spain.
28
CIBER de Epidemiología y Salud Pública (CIBERESP), Melchor Fernández Almagro, 3-5, 28029 Madrid, Spain; Navarre Public Health Institute, Leyre 15, 31003 Pamplona, Spain.
29
Public Health Division of Gipuzkoa, BioDonostia Research Institute, Health Department of Basque Region, Avenida de Navarra, 4-20013 Donostia, San Sebastian, Spain.
30
Department of Clinical Sciences in Malmö, Lund University, 20502 Malmö, Sweden.
31
Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, SE-901 87 Umeå, Sweden; Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, SE-901 87 Umeå, Sweden.
32
Department of Medical Biosciences, Pathology, Umeå University, SE-901 87 Umeå, Sweden.
33
University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0SP, United Kingdom.
34
MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, PO Box 285, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.
35
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Oxford OX3 7LF, United Kingdom.
36
International Agency for Research on Cancer, 150 Cours Albert-Thomas, 69372 Lyon Cedex 08, France.

Abstract

There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, P(trend)=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.

KEYWORDS:

Dietary fats; Ovarian cancer; Serous neoplasms; Unsaturated dietary fats

PMID:
25155210
DOI:
10.1016/j.canep.2014.07.011
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science Icon for Spiral, Imperial College Digital Repository
Loading ...
Support Center