Format

Send to

Choose Destination
Crit Rev Biochem Mol Biol. 2014 Sep-Oct;49(5):426-37. doi: 10.3109/10409238.2014.953626. Epub 2014 Aug 26.

Diversity in ABC transporters: type I, II and III importers.

Author information

1
Department of Molecular Biosciences, Northwestern University , Evanston, IL , USA.

Abstract

ATP-binding cassette transporters are multi-subunit membrane pumps that transport substrates across membranes. While significant in the transport process, transporter architecture exhibits a range of diversity that we are only beginning to recognize. This divergence may provide insight into the mechanisms of substrate transport and homeostasis. Until recently, ABC importers have been classified into two types, but with the emergence of energy-coupling factor (ECF) transporters there are potentially three types of ABC importers. In this review, we summarize an expansive body of research on the three types of importers with an emphasis on the basics that underlie ABC importers, such as structure, subunit composition and mechanism.

KEYWORDS:

ABC transporters; ECF; Type I; Type II; Type III; accessory domain; importers; micronutrient and metal transport; nucleotide binding domain; regulatory domain

PMID:
25155087
PMCID:
PMC4245157
DOI:
10.3109/10409238.2014.953626
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center