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Fertil Steril. 2014 Nov;102(5):1318-23. doi: 10.1016/j.fertnstert.2014.07.1207. Epub 2014 Aug 22.

Blastocyst euploidy and implantation rates in a young (<35 years) and old (≥35 years) presumed fertile and infertile patient population.

Author information

1
Reproductive Endocrinology Associates of Charlotte, Charlotte, North Carolina; University of Kent, School of Biosciences, Canterbury, United Kingdom. Electronic address: tyltaylor@gmail.com.
2
Reproductive Endocrinology Associates of Charlotte, Charlotte, North Carolina.
3
Eastern Virginia Medical School, Jones Institute of Reproductive Medicine, Norfolk, Virginia.
4
University of Kent, School of Biosciences, Canterbury, United Kingdom.

Abstract

OBJECTIVE:

To examine the relationship between blastocyst euploidy and implantation rates in a presumed fertile patient population.

DESIGN:

Retrospective analysis.

SETTING:

Private IVF clinic.

PATIENT(S):

IVF patients undergoing comprehensive chromosome screening (CCS).

INTERVENTION(S):

Embryo biopsy at the blastocyst stage with preimplantation genetic screening using CCS.

MAIN OUTCOME MEASURE(S):

Euploidy, chemical pregnancy, and implantation rates.

RESULT(S):

There was no significant difference in the number of euploid blastocysts between presumed fertile (68/118, 57.6%) and infertile (75/132, 56.8%) patients<35 years old. Likewise, there was no significant difference in the number of euploid blastocysts between presumed fertile (42/86, 48.8%) and infertile (97/206, 47.1%) patients≥35 years old. When those same patients underwent a corresponding frozen embryo transfer cycle, presumed fertile patients demonstrated a significantly higher chemical pregnancy rate when compared with infertile patients, 28/33 (84.8%) and 50/81 (61.7%), respectively. Moreover, presumed fertile patients exhibited significantly higher implantation rates compared with infertile patients, 36/42 (85.7%) and 54/109 (66.7%), respectively.

CONCLUSION(S):

When subdivided by maternal age, no significant difference was seen in blastocyst euploidy rates between presumed fertile and infertile patients; however, chemical pregnancy and implantation rates were significantly higher in a presumed fertile patient population even when transferring only euploid blastocysts. This would indicate that infertility, as a disease, may encompass other aspects such as uterine or other unknown embryological factors that can influence outcomes.

KEYWORDS:

IVF; Preimplantation genetic screening; aneuploidy; comprehensive chromosome screening; embryo biopsy

[Indexed for MEDLINE]

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