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EMBO J. 2014 Oct 1;33(19):2135-6. doi: 10.15252/embj.201489751. Epub 2014 Aug 25.

Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors.

Author information

1
Diabetes Center, University of California-San Francisco, San Francisco, CA, USA.

Abstract

The in vivo assessment of epigenetic changes during mouse pancreatic beta‐cell differentiation reveals surprising differences to directed, in vitro differentiation of human embryonic stem cells. New findings reported in this issue of The EMBO Journal further identify Ezh2 as a critical determinant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapies.

PMID:
25154606
PMCID:
PMC4282500
DOI:
10.15252/embj.201489751
[Indexed for MEDLINE]
Free PMC Article

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