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Curr Opin Virol. 2014 Oct;8:109-15. doi: 10.1016/j.coviro.2014.08.001. Epub 2014 Aug 25.

Human cytomegalovirus intrahost evolution-a new avenue for understanding and controlling herpesvirus infections.

Author information

1
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA.
2
Departments of Pediatrics and Medicine, Divisions of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
3
Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland.
4
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA; Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: timothy.kowalik@umassmed.edu.

Abstract

Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.

PMID:
25154343
PMCID:
PMC4195796
DOI:
10.1016/j.coviro.2014.08.001
[Indexed for MEDLINE]
Free PMC Article

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