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Molecules. 2014 Aug 19;19(8):12630-9. doi: 10.3390/molecules190812630.

Studies of the in vitro antibacterial activities of several polyphenols against clinical isolates of methicillin-resistant Staphylococcus aureus.

Author information

1
Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. msuer@126.com.
2
Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. ortho_zhu@hotmail.com.
3
Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. mzhuzhu@tom.com.
4
Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. wanghong1812@163.com.
5
Department of Infection and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. zsw1106@sina.cn.

Abstract

In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects.

PMID:
25153875
PMCID:
PMC6271679
DOI:
10.3390/molecules190812630
[Indexed for MEDLINE]
Free PMC Article

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