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Trends Endocrinol Metab. 2014 Nov;25(11):558-66. doi: 10.1016/j.tem.2014.07.002. Epub 2014 Aug 19.

Protein and amino acid restriction, aging and disease: from yeast to humans.

Author information

1
Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
2
Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.

Abstract

Many of the effects of dietary restriction (DR) on longevity and health span in model organisms have been linked to reduced protein and amino acid (AA) intake and the stimulation of specific nutrient signaling pathways. Studies in yeast have shown that addition of serine, threonine, and valine in media promotes cellular sensitization and aging by activating different but connected pathways. Protein or essential AA restriction extends both lifespan and healthspan in rodent models. In humans, protein restriction (PR) has been associated with reduced cancer, diabetes, and overall mortality. Thus, interventions aimed at lowering the intake of proteins or specific AAs can be beneficial and have the potential to be widely adopted and effective in optimizing healthspan.

KEYWORDS:

calorie restriction; dietary intervention; fasting mimicking diet (FMD); healthspan; longevity

PMID:
25153840
PMCID:
PMC4254277
DOI:
10.1016/j.tem.2014.07.002
[Indexed for MEDLINE]
Free PMC Article

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