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Arch Pediatr. 2014 Sep;21(9):1062-70. doi: 10.1016/j.arcped.2014.06.020. Epub 2014 Aug 19.

[Is the new vaccination schedule recommended in France adapted to premature babies?].

[Article in French]

Author information

Service de pédiatrie, hôpital Jean-Verdier, hôpitaux universitaires Paris-Seine-Saint-Denis, avenue du 14-Juillet, 93143 Bondy cedex, France.
Service de pédiatrie néonatale et réanimation, université de Rouen, CHU Charles-Nicolle, 76031 Rouen cedex, France.
Service de réanimation néonatale, hôpital Antoine-Béclère, 157, rue de la Porte-Trivaux, 92140 Clamart, France.
AFPA, 34090 Montpellier, France.
AFPA, 67, rue Alexandre-Dumas, 73100 Aix-Les-Bains, France.
Centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France.
Centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil cedex, France.
AFPA, 02100 Saint-Quentin, France.
AFPA, 21000 Dijon, France.
PMI, DFPE, 94-96, Quai de la Rapée, 75570 Paris, France.
Service de pédiatrie et de néonatalogie, centre hospitalier de l'ouest guyanais, 97320 Saint-Laurent du Maroni, France.
Groupe de pédiatrie tropicale de la Société française de pédiatrie, Paris, France.
Pôle de périnatologie, hôpital Robert-Debré, université Paris 7 Denis Diderot, Assistance publique-Hôpitaux de Paris, 75018 Paris, France.
Université Paris VII, 28, rue Parmentier, 92200 Neuilly-sur-Seine, France.
Service de néonatologie, unité court séjour, petits nourrissons, centre hospitalier intercommunal de Créteil, 36, avenue de Verdun, 94000 Créteil, France. Electronic address:


The French 2013 immunization schedule having a goal of simplification with comparable efficacy, has decreased the number of injections and removed the injection performed at three months of age in the general population. Apart from the prevention of invasive pneumococcal infections for which it is recommended to maintain three dose primary immunization, vaccination of premature is not addressed in this new calendar. Can the extremely preterm infants (<33 weeks of gestational age) benefit from this new schedule or should we keep them in three injections schedule? The objective of this paper is to clarify this point through the data available in the literature. Children born prematurely and especially the "extremely premature" born before 33 weeks are at high risk of infections, some of them are preventable by immunization. Although there is no clinical evidence, for pertussis, pneumococcus, Haemophilus influenzae b, hepatitis B, whatever the immunogenicity criteria, immunogenicity is significantly lower in preterm than in term newborn after 3 doses primary schedule. This lower immunogenicity raises concerns about the transition to two doses, about the ability to give short term protection and booster responses. Given these data, GPIP takes the position for maintaining a primary 3-dose vaccination at 2.3 and 4 months for premature infants less than 33 weeks.

[Indexed for MEDLINE]

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