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Psychiatr Clin North Am. 2014 Sep;37(3):393-413. doi: 10.1016/j.psc.2014.06.003. Epub 2014 Jul 23.

Neuromodulation in obsessive-compulsive disorder.

Author information

1
Department of Psychiatry, Academic Medical Center, Meibergdreef 5, Amsterdam 1105 AZ, The Netherlands.
2
Department of Psychiatry, Academic Medical Center, Meibergdreef 5, Amsterdam 1105 AZ, The Netherlands; Neuromodulation & Behavior group, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, Amsterdam 1105 BA, The Netherlands. Electronic address: ddenys@gmail.com.

Abstract

Neuromodulation techniques in obsessive-compulsive disorder (OCD) involve electroconvulsive therapy (ECT), transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), and deep brain stimulation (DBS). This article reviews the available literature on the efficacy and applicability of these techniques in OCD. ECT is used for the treatment of comorbid depression or psychosis. One case report on tDCS showed no effects in OCD. Low-frequency TMS provides significant but mostly transient improvement of obsessive-compulsive symptoms. DBS shows a response rate of 60% in open and sham-controlled studies. In OCD, it can be concluded that DBS, although more invasive, is the most efficacious technique.

KEYWORDS:

Deep brain stimulation (DBS); Efficacy; Electroconvulsive therapy (ECT); Neuromodulation; Obsessive-compulsive disorder (OCD); Review; Transcranial direct current stimulation (tDCS); Transcranial magnetic stimulation (TMS)

PMID:
25150569
DOI:
10.1016/j.psc.2014.06.003
[Indexed for MEDLINE]

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