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Exp Cell Res. 2014 Dec 10;329(2):248-54. doi: 10.1016/j.yexcr.2014.08.017. Epub 2014 Aug 19.

Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis.

Author information

1
The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA 94143, USA.
2
The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: pietrase@stemcell.ucsf.edu.

Abstract

Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the regulatory factors that maintain proper HSC function and lineage output under normal conditions are well understood, significantly less is known about how HSC fate is regulated in response to inflammation or disease. As many blood disorders are associated with overproduction of pro-inflammatory cytokines, significant interest has emerged in understanding the impact of these factors on HSC function. In this review we highlight key advances demonstrating the impact of pro-inflammatory cytokines on the biology of HSCs and the BM niche, and address ongoing questions regarding their role in normal and pathogenic hematopoiesis.

KEYWORDS:

Cytokine; Hematopoietic stem cell; Inflammation; Interferon; Interleukin; Myeloproliferative neoplasm

PMID:
25149680
PMCID:
PMC4250307
DOI:
10.1016/j.yexcr.2014.08.017
[Indexed for MEDLINE]
Free PMC Article

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