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Vaccine. 2014 Sep 29;32(43):5657-61. doi: 10.1016/j.vaccine.2014.08.011. Epub 2014 Aug 20.

Safety and immunogenicity of a quadrivalent human papillomavirus vaccine in HIV-infected and HIV-negative adolescents and young adults.

Author information

1
Department of Pediatrics, Luigi Sacco Hospital, University of Milan, Italy.
2
Department of Immunology, Luigi Sacco Hospital, University of Milan, Italy.
3
Department of Pediatrics, Luigi Sacco Hospital, University of Milan, Italy. Electronic address: doc.alessandra.vigano@gmail.com.
4
Department of Immunology, Luigi Sacco Hospital, University of Milan, Italy; Don C Gnocchi Foundation, IRCCS, Milan, Italy.
5
Clinical Epidemiology Unit, Liver Research Center, Basovizza, Trieste, Italy.

Abstract

Human papillomavirus (HPV) infection is highly prevalent and can lead to cancer; the development of safe and efficacious vaccines for HPV is a major public health concern. The two licensed HPV vaccines contain recombinant virus-like particles of HPV 16 and 18; one of such vaccines also protects against HPV types 6 and 11 which cause genital warts. We determined safety and immunogenicity of quadrivalent HPV vaccine in HIV-infected and HIV-negative adolescents and young adults, aged 13-27 years. The seroconversion rate, assessed by antibody titers, 1 month after the administration of the third vaccine dose was 0.85 (95% CI 0.75-0.95) in the HIV-infected group and 0.91 (0.83-0.99) in the HIV-negative subjects (p=0.52). The vaccine was generally safe and well tolerated; the most common side effect was local pain and the most frequent systemic side effect was headache. This is the first report on response to HPV vaccination in both female and male HIV-infected adolescents and young adults and highlights that this population may benefit from HPV immunoprophylaxis. Further studies are needed to examine the long term efficacy of this vaccine in HIV-infected individuals.

KEYWORDS:

HIV; HPV; Quadrivalent HPV vaccine

PMID:
25149430
DOI:
10.1016/j.vaccine.2014.08.011
[Indexed for MEDLINE]

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