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J Pediatr Surg. 2014 Sep;49(9):1363-6. doi: 10.1016/j.jpedsurg.2014.02.081. Epub 2014 Feb 26.

Growth in children with congenital diaphragmatic hernia during the first year of life.

Author information

1
Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia; Medical School, University of Groningen, Groningen, the Netherlands. Electronic address: l.leeuwen1@gmail.com.
2
Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia; Grace Centre for Newborn Care, The Children's Hospital at Westmead, Sydney, Australia.
3
Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia; Department of Paediatric Surgery, The Children's Hospital at Westmead, Sydney, Australia.
4
Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia.

Abstract

PURPOSE:

Infants with congenital diaphragmatic hernia (CDH) have high rates of mortality and long-term morbidity, including poor growth and failure to thrive. The aim of this study was to describe growth patterns during the first year of life in infants with congenital diaphragmatic hernia in a non-ECMO cohort.

METHODS:

Medical records of infants with CDH admitted to our center between January 2005 and December 2011 were reviewed. Infants with anthropometric measurements at 3, 6 and 12months were included. Anthropometric measurements were obtained for the first year of life. Logistic regression analyses were performed to find predictive associations with failure to thrive (FTT).

RESULT:

Of the 45 survivors, 38 were seen twice (84%) and 24 (53%) were seen on three occasions to age 12months. Poor growth was observed with weight being most affected. FTT was present in 63% during the first six months of life. Days of mechanical ventilation were the only predictor of FTT. Besides poor weight gain, height and head circumference were also reduced. However, catch-up growth occurred during the second half of infancy and at age 12months failure to thrive had reduced by two thirds to 21%.

CONCLUSIONS:

Poor growth is a common early finding in CDH patients, which improves during infancy. This emphasizes the importance of close follow-up and aggressive nutritional management in CDH patients.

KEYWORDS:

Congenital diaphragmatic hernia; Failure to thrive; Growth; Height; Weight

PMID:
25148738
DOI:
10.1016/j.jpedsurg.2014.02.081
[Indexed for MEDLINE]

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