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J Infect Dis. 2015 Feb 1;211(3):361-5. doi: 10.1093/infdis/jiu464. Epub 2014 Aug 21.

Origin of HTLV-1 in hunters of nonhuman primates in Central Africa.

Author information

1
Institut Pasteur de Bangui, Réseau International des Instituts Pasteur, Central African Republic Unité de Rétrovirologie, Centre International de Recherches Médicales de Franceville, Gabon.
2
Unité de Rétrovirologie, Centre International de Recherches Médicales de Franceville, Gabon.
3
Equipe Oncogenèse Rétrovirale, équipe labelisée "Ligue Contre le Cancer" U1111 CIRI, Ecole Normale Supérieure de Lyon.
4
Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes and UMR CNRS 3569, Institut Pasteur, Paris, France.

Abstract

Of 78 Gabonese individuals who had received bites from nonhuman primates (NHPs) while hunting, 7 were infected with human T lymphotropic virus (HTLV-1). Five had been bitten by gorillas and were infected with subtype B strains; however, a 12-year-old girl who was severely bitten by a Cercopithecus nictitans was infected with a subtype D strain that was closely related to the simian T lymphotropic virus (STLV-1) that infects this monkey species. Her mother was infected with a subtype B strain. These data confirm that hunters in Africa can be infected by HTLV-1 that is closely related to the strains circulating among local NHP game. Our findings strongly suggest that a severe bite represent a risk factor for STLV-1 acquisition.

KEYWORDS:

Gabon; HTLV-1; STLV-1; human infection; interspecies transmission; wild-born nonhuman primate

PMID:
25147276
DOI:
10.1093/infdis/jiu464
[Indexed for MEDLINE]

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