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Bioorg Chem. 2014 Dec;57:231-41. doi: 10.1016/j.bioorg.2014.07.003. Epub 2014 Aug 1.

Human lysyl oxidase-like 2.

Author information

1
Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.
2
Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA. Electronic address: mmure@ku.edu.

Abstract

Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu(2+)- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2.

KEYWORDS:

Cell signaling; Extracellular matrix; Lysine tyrosylquinone (LTQ); Lysyl oxidase family; Lysyl oxidase like-2; Tumor metastasis/invasion

PMID:
25146937
PMCID:
PMC6309629
DOI:
10.1016/j.bioorg.2014.07.003
[Indexed for MEDLINE]
Free PMC Article

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