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Adv Healthc Mater. 2015 Feb 18;4(3):356-60. doi: 10.1002/adhm.201400297. Epub 2014 Aug 21.

Anisotropic cellular network formation in engineered muscle tissue through the self-organization of neurons and endothelial cells.

Author information

1
Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Abstract

Tissue anisotropy directed by cell sheets: Aligned myoblasts can be harvested as an anisotropic cell sheet using a micropatterned thermoresponsive substrate. Neurons and endothelial cells sandwiched between multiple anisotropic cell sheets self-organize oriented cellular networks in the tissue construct. This simple tissue engineering technique is useful for the creation of biomimetic microstructures in complex tissue, required for future advances in regenerative medicine.

KEYWORDS:

cell orientation; cell sheets; iPS cells; neurons; tissue engineering

PMID:
25146917
DOI:
10.1002/adhm.201400297
[Indexed for MEDLINE]

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