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Biomarkers. 2014 Nov;19(7):585-9. doi: 10.3109/1354750X.2014.952663. Epub 2014 Aug 22.

Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run.

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1
Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília , Brasília, DF , Brazil .

Abstract

CONTEXT:

Circulating miRNAs are potential biomarkers that can be important molecules driving cell-to-cell communication.

OBJECTIVE:

To investigate circulating muscle-specific miRNAs in recreational athletes.

MATERIALS AND METHODS:

Three miRNAs from whole plasma before and after a half-marathon were analyzed by qPCR.

RESULTS:

MiR-1, -133a, and -206 significantly increased after the race.

DISCUSSION:

Increased levels of miRNAs after exercise point to potential biomarkers and to the possibility of being functional players following endurance training.

CONCLUSION:

These miRNAs are potential biomarkers of muscle damage or adaptation to exercise.

KEYWORDS:

Exercise; extracellular vesicles; microRNA; plasma; quantitative PCR

PMID:
25146754
DOI:
10.3109/1354750X.2014.952663
[Indexed for MEDLINE]
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